Pharmaceuticals | Free Full-Text | Selective COX-2 Inhibitors: Road from Success to Controversy and the Quest for Repurposing
Biochemical selectivity, assessed as COX-1/COX-2 IC 50 values of... | Download Table
Binding of Ibuprofen, Ketorolac, and Diclofenac to COX-1 and COX-2 Studied by Saturation Transfer Difference NMR | Journal of Medicinal Chemistry
Lessons from 20 years with COX‐2 inhibitors: Importance of dose–response considerations and fair play in comparative trials - Stiller - 2022 - Journal of Internal Medicine - Wiley Online Library
Emerging Evidence in NSAID Pharmacology: Important Considerations for Product Selection
A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385*
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis | PNAS
PharmaConnect on X: "🔸NSAIDs & COX Enzymes🔸 ▪️NSAIDs inhibit prostaglandin synthesis from arachidonic acid by inhibiting COX. ▪️There are two major isoforms of COX: ▫️COX-1 (constitutive) ▫️COX-2 (inducible) ▪️The therapeutic benefits of
nsaid_side_effects [TUSOM | Pharmwiki]
COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs - The Lancet
Selectivity of NSAiDs for COX-1 and COX-2. Notes: (A) Relationship... | Download Scientific Diagram
Relative COX-1/COX-2 selectivity of various nonselective NSAIDs. Note:... | Download Scientific Diagram
Visual summary of the COX-1 and/or COX-2 inhibiting properties of the... | Download Scientific Diagram
Emerging Evidence in NSAID Pharmacology: Important Considerations for Product Selection
Cyclooxygenase Inhibition and Cardiovascular Risk | Circulation
Structural and Functional Basis of Cyclooxygenase Inhibition | Journal of Medicinal Chemistry
Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate adenocarcinoma xenograft model | BMC Urology | Full Text
Cox-1 and Cox-2 inhibitor for treatment acute chronic pain, what's the difference?
JCI - Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities
COX-1 vs COX-2 selectivity In-vitro - The Pain Source
Pharmaceuticals | Free Full-Text | Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks
Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells | Scientific Reports